UCSF researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs – checkpoint inhibitors.
Researchers identified a protein that cancer cells use as a shield to protect the PI3K pathway against targeted drugs, and showed that blocking this protein allowed previously ineffective therapies to slow cancer cell growth and shrink tumors.
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
Each year, 300,000 infants worldwide are born with sickle cell. UCSF Benioff Children’s Hospitals are at the the leading edge of advancements to cure sickle cell disease.
Scientists have used ultra-high-resolution cryo–electron microscopy to capture the most detailed portrait ever of an opioid drug triggering the biochemical signaling cascade that gives it its power.
Lloyd Hollingsworth “Holly” Smith Jr., a visionary physician-scientist whose uncompromising quest for excellence over a career spanning half a century helped transform UCSF into the world-renowned health sciences university it is today, died peacefully at his home on June 18.