In the 1970s, some researchers recognized that facial hemangiomas like port-wine stain were associated with certain cerebrovascular anomalies. But it wasn't until 10 years ago that UCSF researcher Ilona Frieden, MD, and her colleagues recognized and described the association between facial hemangiomas and a wide variety of disorders like seizures, glaucoma, cardiac disorders, and various brain and cerebrovascular malformations.