About 1 in 5 people with high blood pressure or hypertension have a form of the condition that is resistant to medication. These patients may have tried lifestyle changes or multiple medications at their highest doses without achieving optimal management of their condition. Without adequate control, a person with high blood pressure has an increased risk of heart attacks, strokes, heart failure, and kidney failure.

Advanced colon cancer is the leading cause of cancer-related death in young American men and the second highest worldwide. In the majority of these patients, as the cancer advances it metastasizes to the liver. Despite progress in surgical therapies aimed at eradicating the cancer, many of these patients will have tumor recurrence in the liver.