Non-Opioid Compounds Squelch Pain Without Sedation
A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
University of California San Francisco
A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
UCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.
UCSF Health’s Heart and Vascular Center is welcoming Sammy Elmariah, MD, MPH, FACC, FAHA, FSCAI, as chief of its division of Interventional Cardiology and medical director of the division’s cardiac catheterization lab. Elmariah is a recognized expert in structural heart disease interventions and catheter-based valve therapies.
A mortality prediction model for older adults with dementia may help physicians determine which treatments to provide while facilitating decision-making for patients and their families.
UCSF researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
Using equations to calculate kidney function that do not include race adjustments would result in Black patients gaining time before their kidneys fail.
Researchers have found significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, showing new pathways for potential treatment.
A new therapy pulls forward a mutated version of the KRAS protein to help the immune system recognize and destroy cancer cells.
Children living in neighborhoods with greater hardships, such as substandard housing or high pollution, are more likely to use emergency departments, including for complaints that could be managed by their pediatricians, a new study led by UCSF Benioff Children’s Hospitals found.
UCSF-led research outlines the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. Their findings could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease.
A UCSF study found that step counts, a measure of physical activity, were markedly lower early in the COVID-19 pandemic than pre-pandemic and remained lower on average in the two years following the onset of the global pandemic.
Pregnant women in the U.S. are being exposed to chemicals like melamine, cyanuric acid, and aromatic amines that can increase the risk of cancer and harm child development, according to a study from researchers at UCSF and Johns Hopkins Bloomberg School of Public Health.
The study, funded by the National Institute on Aging, recruited people who were 50 and older and homeless, and followed them for a median of 4.5 years. By interviewing people every six months about their health and housing status, researchers were able to examine how things like regaining housing, using drugs, and having various chronic conditions, such as diabetes, affected their risk of dying.
About 50% of all mothers of children with autism spectrum disorder (ASD) had elevated levels of depressive symptoms over 18 months, while rates were much lower (6% to 13.6%) for mothers with neurotypical children in the same period, UCSF researchers report in a new study.
Most people are at risk for periodic loneliness, but for midlife and older adults who identify as Hispanic/Latinx, or who live in poverty, loneliness may be less likely to resolve over time.
When our eyes move during REM sleep, we’re gazing at things in the dream world our brains have created, according to a new study by UCSF researchers. The findings shed light not only into how we dream, but also into how our imaginations work.
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
A new UCSF study sheds light on the diversity within the most common type of pediatric liver tumor and suggests a way forward for more precise chemotherapy treatment.
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
According to a new UCSF study, screening for depression at the primary care level could dramatically increase the likelihood of treatment for those who are traditionally undertreated — racial and ethnic minority individuals, older adults, those with limited English proficiency and men.
A new national study led by UCSF found that more sophisticated devices that pair with smartphones don’t lead to better blood pressure control than home-use blood pressure cuffs.
The repercussions of overturning Roe v. Wade – and the failure of the Supreme Court to provide any guidance on exceptions related to the life and health of the mother – are potentially catastrophic for women who face a life-threating diagnosis of pregnancy associated cancers (PAC).
The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a potential new path to treating Alzheimer’s and other forms of dementia, according to a new study from UCSF researchers.
UCSF, San Francisco Department of Public Health (SFDPH) and San Mateo County Health (SMC Health) are partnering with local community groups to learn about long COVID. Their project, Let’s Figure Out Long COVID – Tell Us Your Story, Bay Area, will call local residents of all ethnicities and backgrounds who previously had COVID.
Blood tests taken within 24 hours of a traumatic brain injury (TBI) flag which patients are likely to die and which patients are likely to survive with severe disability, according to a study headed by UCSF, the University of Pennsylvania and the University of Michigan.
UCSF researchers are part of a $200 million global consortium to develop new diagnostics, therapeutics, containment and control strategies to reduce the suffering from tuberculosis (TB) around the world.
A new UCSF study reports for the first time that significant hearing issues often occur among adult survivors of the most common forms of cancer.
San Francisco’s pandemic policy of offering hotel rooms, meals, and medical services to unhoused populations saw the unintended benefit of dramatically lowering the use of emergency medical services.
Tweens who spend more time on screens have a higher likelihood of developing disruptive behavior disorders, with social media having an especially strong influence, a new UCSF-led study found.